BlendLipo-B B12
Lipotropic B-Complex with Vitamin B12 (Methionine / Inositol / Choline / Cyanocobalamin)
Lipo-B with Vitamin B12 is a specialized multi-component formulation comprising key lipotropic compounds—Methionine, Inositol, and Choline (MIC)—supplemented with Vitamin B12 (Cobalamin). In scientific investigations, this combination is utilized to study metabolic dynamics, lipid transport, and the enzymatic breakdown of fats within hepatic and peripheral tissues. The individual constituents are selected for their cooperative roles in one-carbon metabolism, phospholipid synthesis, and cellular methylation. Researchers deploy this blend in experimental frameworks to evaluate cellular energy production, the regulation of hepatic lipid accumulation, and homocysteine homeostasis.
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- Purity
- ≥99%
- Form
- USP Liquid
- Available sizes
- 10ml
Mechanism of Action
The constituents of Lipo-B function through distinct yet complementary biochemical pathways. Methionine serves as a critical sulfur-containing amino acid and precursor to S-adenosylmethionine (SAMe), driving transmethylation reactions. Choline and Inositol are foundational to phosphatidylcholine and phospholipid synthesis, which are essential for the structural assembly of very-low-density lipoproteins (VLDL) and the mobilization of triglycerides from hepatocytes. Vitamin B12 serves as an essential cofactor for methionine synthase and methylmalonyl-CoA mutase. It facilitates the remethylation of homocysteine to methionine and assists in the entry of odd-chain fatty acids into the citric acid cycle. Together, the formulation provides an integrated model for investigating lipid oxidation, methylation efficiency, and mitochondrial energy dynamics in laboratory models.
Research Areas
- ●Hepatic lipid export and steatosis research
- ●One-carbon metabolism and methylation pathways
- ●Cellular phospholipid and VLDL synthesis
- ●Mitochondrial energy and fatty acid oxidation
- ●Homocysteine clearance mechanisms
Selected References
- Zeisel SH et al., Annu Rev Nutr, 2006
- Corbin KD, Zeisel SH, Curr Opin Clin Nutr Metab Care, 2012
- Froese DS et al., J Inherit Metab Dis, 2019
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