PEG-MGF
Pegylated Mechano Growth Factor
Pegylated Mechano Growth Factor (PEG-MGF) is a stabilized synthetic analogue of Mechano Growth Factor, an alternative splice variant of Insulin-like Growth Factor-1 (IGF-1Ec). Naturally expressed in response to mechanical overload and muscular stress, endogenous MGF acts locally to stimulate satellite cell activation and tissue remodeling. However, native MGF exhibits a very brief physiological half-life due to rapid enzymatic degradation. The pegylation process attaches a polyethylene glycol moiety to the peptide backbone, shielding it from enzymatic cleavage and significantly extending its systemic stability. This molecular modification allows researchers to evaluate extended signaling dynamics and cellular regenerative pathways in experimental models without the confounding factor of rapid peptide breakdown.
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- Purity
- ≥99%
- Form
- Lyophilized powder
- CAS Number
- 1202044-20-9
- Molecular Formula
- C121H200N42O39 (peptide base)
- Molecular Weight
- 2867.2 g/mol (peptide base)
- Available sizes
- 2mg
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Mechanism of Action
PEG-MGF functions primarily by stimulating satellite cell proliferation and migration within myogenic models, operating through pathways distinct from systemic IGF-1 receptor activation. While mature IGF-1 primarily promotes myoblast differentiation and protein synthesis, MGF signaling is predominantly involved in the early proliferative phase following cellular strain, preventing premature differentiation and expanding the local progenitor pool. In addition to skeletal muscle research, investigative models have shown PEG-MGF activity in neuroprotective assays and cardiac ischemia models, where it appears to modulate cell survival cascades, downregulate apoptotic markers, and support structural tissue recovery.
Research Areas
- ●Myogenesis and satellite cell proliferation
- ●Muscle injury recovery models
- ●Neuroprotective signaling mechanisms
- ●Cardiovascular repair pathways
- ●Comparative pharmacokinetics of pegylated peptides
Selected References
- Goldspink G. Research on mechano growth factor. J Anat. 2005.
- Ates K, et al. Mechano growth factor promotes satellite cell proliferation. FEBS Lett. 2007.
- Dluzniewska J, et al. MGF-derived peptide mediates neuroprotection. Neurochem Int. 2005.
- Philippou A, et al. The role of IGF-1 isoforms in skeletal muscle. In Vivo. 2007.
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