SNAP-8
Acetyl Octapeptide-3
SNAP-8 (Acetyl Octapeptide-3) is an elongated octapeptide derivative of the hexapeptide Argireline (Acetyl Hexapeptide-8), modeled after the N-terminal domain of the synaptosomal-associated protein 25 (SNAP-25). In biochemical research, SNAP-8 is utilized to study targeted modulation of neuromuscular signaling pathways and the inhibition of vesicle docking. By serving as a competitive inhibitor of native SNAP-25, SNAP-8 enables researchers to evaluate the modulation of calcium-dependent neurotransmitter release. In vitro models frequently employ this peptide to examine the mechanics of expression-related muscle contractions and epidermal matrix dynamics.
Choose how to buy
Subscribe & save 5% on reshipsYour first order ships at the regular price. Every reship after that is 5% off. Pause, change the interval, or cancel anytime.
- Purity
- ≥99%
- Form
- Lyophilized powder
- CAS Number
- 868844-74-0
- Molecular Formula
- C41H70N16O16S
- Molecular Weight
- 1075.16 g/mol
- Available sizes
- 10mg
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Mechanism of Action
SNAP-8 functions by competing with native SNAP-25 for position within the ternary SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor) complex. When SNAP-8 integrates into the complex in place of SNAP-25, the complex cannot effectively mediate the fusion of synaptic vesicles with the presynaptic membrane. This structural disruption reduces calcium-dependent exocytosis of acetylcholine at the neuromuscular junction, leading to a decrease in downstream muscle cell stimulation and attenuation of repetitive mechanical stress in tissue models.
Research Areas
- ●SNARE complex assembly and modulation
- ●Neuromuscular junction signaling
- ●Neurotransmitter exocytosis inhibition
- ●Cosmetic biochemistry and dermal remodeling
- ●Cellular anti-wrinkle kinetics
Selected References
- Gutiérrez et al., Int J Cosmet Sci, 2003
- Ruiz et al., J Pept Res, 2004
- Lupo MP, Cole AL, J Clin Aesthet Dermatol, 2007
Related Products
