Cartalax
Cartalax (Ala-Glu-Asp)
Cartalax is a short synthetic peptide bioregulator composed of the amino acid sequence Alanine-Glutamic Acid-Aspartic Acid (AED). Developed in the field of peptide-based tissue bioregulation, Cartalax was designed to mirror endogenous peptide fractions that interact directly with the cellular machinery of cartilage and connective tissue. In laboratory research models, Cartalax is utilized to examine structural protein synthesis, chondrocyte proliferation rates, and cellular differentiation pathways. Researchers investigate its capacity to stimulate extracellular matrix (ECM) component production, such as collagen and proteoglycans, in degenerated or mechanically stressed connective tissue substrates. Because of its low molecular weight and tissue-specific biomimetic activity, Cartalax serves as a primary tool for exploring potential therapeutic pathways in degenerative joint diseases, cartilage wear, and age-related extracellular matrix degradation in vitro and in vivo.
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- Purity
- ≥99%
- Form
- Lyophilized powder
- Molecular Formula
- C12H19N3O8
- Molecular Weight
- 333.29 g/mol
- Available sizes
- 20mg
Sequence
H-Ala-Glu-Asp-OH
Mechanism of Action
Cartalax is believed to function through epigenetic and transcriptional regulatory mechanisms within chondrocytes and fibroblasts. Due to its short sequence, the tripeptide can penetrate cellular and nuclear membranes to interact directly with nucleosomes and specific DNA regions, stimulating gene expression associated with structural cartilage components. Research indicates that Cartalax modulates the expression of type II collagen, aggrecan, and cartilage oligomeric matrix protein (COMP). Concurrently, investigations demonstrate that it downregulates pro-inflammatory markers and matrix metalloproteinases (MMPs), thereby suppressing enzymatic degradation of the extracellular matrix in laboratory cartilage culture models.
Research Areas
- ●Cartilage and connective tissue regeneration
- ●Osteoarthritis and joint wear disease models
- ●Chondrocyte proliferation and viability
- ●Extracellular matrix (ECM) protein synthesis
- ●Fibroblast and connective tissue gene regulation
Selected References
- Khavinson VKh et al. Bull Exp Biol Med. 2011;151(6):730-733.
- Khavinson VKh et al. Biogerontology. 2014;15(6):609-619.
- Lin'kova NS et al. Adv Gerontol. 2016;29(4):612-616.
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